发明名称 |
OLIGONUCLEOTIDES FOR TREATMENT OF PROSTATE AND OTHER CANCERS |
摘要 |
The present invention makes use of therapeutic agents which target heat shock protein (hsp) 27 in vivo to provide treatment to individuals, particularly human individuals, suffering from prostate cancer and other cancers that overexpress hsp 27. In accordance with the invention, a therapeutic agent, for example an antisense oligonucleotide or RNAi nucleotide inhibitor with sequence specificity for hsp 27 mRNA, for example human hsp 27 mRNA, is administered to an individual suffering from prostate cancer or some other cancer expressing elevated levels of hsp 27 in a therapeutically effective amount. The therapeutic agent is suitably formulated into a pharmaceutical composition which includes a pharmaceutically aceptable carrier, and packaged in dosage unit form. A preferred dosage unit form is in injectable dosage unit form. |
申请公布号 |
EP1545561(A2) |
申请公布日期 |
2005.06.29 |
申请号 |
EP20030769111 |
申请日期 |
2003.10.02 |
申请人 |
THE UNIVERSITY OF BRITISH COLUMBIA |
发明人 |
GLEAVE, MARTIN, E.;ROCCHI, PALMA;SIGNAEVSKY, MAXIM;BERALDI, ELIANA |
分类号 |
A61K31/7125;A61K31/713;A61K48/00;A61P35/00;C12N15/113 |
主分类号 |
A61K31/7125 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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