发明名称 |
PHARMACEUTICAL COMPOSITIONS COMPRISING AN HIV ENVELOPE PROTEIN AND CD4 |
摘要 |
<p>Pharmaceutical composition for treating/preventing HIV comprising (i) a polynucleotide encoding HIV envelope protein and (ii) a polynucleotide encoding CD4 receptor protein or; (i) a polynucleotide encoding HIV envelope protein and (ii) a CD4 receptor protein or; a fixed cell expressing an HIV envelope protein complexed with a CD4 receptor protein. Also disclosed are pharmaceutical compositions for treating/preventing HIV comprising an antibody immunospecific for a fixed cell expressing an HIV envelope protein complex with a CD4 receptor protein. The binding of the CD4 to the HIV envelope protein, i.e. gp120, exposes hidden epitopes that may be used as targets in immunotherapy; the presentation of the gp120 and CD4 in the present forms is said to overcome problems with prior art soluble gp120-CD4 complexes.</p> |
申请公布号 |
EP1545602(A1) |
申请公布日期 |
2005.06.29 |
申请号 |
EP20030784418 |
申请日期 |
2003.08.12 |
申请人 |
FONDAZIONE CENTRO SAN RAFFAELE DEL MONTE TABOR |
发明人 |
LUSSO, PAOLO;BURASTERO, SAMUELE, E. |
分类号 |
A61K38/17;A61K39/21;A61P29/00;A61P31/18;C07K14/16;C07K14/705;C07K14/73;C07K16/10;C07K16/28;C12N5/078;C12N15/62;(IPC1-7):A61K39/21;A61K35/12;C12N5/16;A61K39/42 |
主分类号 |
A61K38/17 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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