| 发明名称 |
TRANSGENIC ANIMAL MODELS FOR CARDIAC HYPERTROPHY AND USES THEREOF |
| 摘要 |
<p>The present invention relates to the use of a composition inhibiting the activity of CaMKIV and modulating the activity of at least one gene or gene product that is expressed in cardiomyocytes in response to a hypertrophic signal for the manufacture of a medicament for the treatment of cardiac hypertrophy, decompensated cardiac hypertrophy, compound cardiac hypertrophy, dilated cardiac hypertrophy, and heart failure.</p> |
| 申请公布号 |
EP1025216(B1) |
申请公布日期 |
2005.06.29 |
| 申请号 |
EP19980953672 |
申请日期 |
1998.10.16 |
| 申请人 |
THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM;UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTER |
发明人 |
GRANT, STEPHEN, R.;OLSON, ERIC, N.;MOLKENTIN, JEFFREY, D. |
| 分类号 |
A01K67/027;A61K31/436;A61K31/453;A61K31/711;A61K38/00;A61K39/395;A61K45/00;A61K48/00;A61K49/00;A61P9/04;A61P43/00;C07K14/58;C12N5/08;C12N15/09;C12N15/85;C12Q1/02;G01N33/50;(IPC1-7):C12N15/00;A61K31/435 |
主分类号 |
A01K67/027 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
