发明名称 |
Process for high-yield synthesis of nucleic acid arrays |
摘要 |
<p>Protective groups which may be cleaved with an activatable deprotecting reagents are employed to achieve a highly sensitive, high resolution, combinatorial synthesis of pattern arrays of diverse polymers. In preferred embodiments of the instant invention, the activatable deprotecting reagent is a photoacid generator and the protective groups are DMT for nucleic acids and tBOC for amino acids. This invention has a wide variety of applications and is particularly useful for the solid phase combinatorial synthesis of polymers.</p> |
申请公布号 |
EP1547678(A2) |
申请公布日期 |
2005.06.29 |
申请号 |
EP20040258031 |
申请日期 |
2004.12.22 |
申请人 |
AFFYMETRIX, INC. (A DELAWARE CORPORATION) |
发明人 |
MCGALL, GLENN H.;KUIMELIS, ROBERT G.;GOLDBERG, MARTIN J.;XU, GUANGYU;PARKER, NINEVEH |
分类号 |
B01J19/00;B82Y30/00;C07H21/00;C07H21/04;C12M1/34;C12Q1/68;C40B40/06;C40B40/10;C40B40/12;C40B50/14;C40B60/14;(IPC1-7):B01J19/00 |
主分类号 |
B01J19/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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