4-ARYLISOINDOLE ANALGESICS

摘要

The 4-arylisoindoles of formula (I) are effective analgesics including stereoisomers and pharmaceutically acceptable salts thereof, wherein (II) is (III), (IV) or (V); with the proviso that there is 0 or 1 unsaturated bond in the isoindole ring and with the proviso that where the stereoisomer is: a) the 3a.beta., 4.beta., 7a.alpha. diastereomer, then a double bond joints the 5- and 6-position carbons or the 6- and 7-position carbons; b) the 3a.beta., 4.alpha., 7a.alpha. or the 3a.beta., 4.alpha., 7a.beta. diastereomers, then the double bond joins the 5- and 6-position carbons; and c) the 3a.beta., 4.beta., 7a.beta. diastereomer, then the double bond joins the 6- and 7- position carbons.