发明名称 |
PYRAZOLO[1,5-A]PYRIMIDINE DERIVATIVES |
摘要 |
The present invention provides pyrazolo[1,5- a]pyrimidine derivatives represented by the formula (1) (See formula I) wherein R1 represents lower alkyl or the like; one of R2 and R3 represents hydrogen and the other represents phenyl having lower alkoxy or the like, and R4 is hydrogen, carboxyl, lower alkoxy-carbonyl or the like. The derivatives of the invention have pharmacological effects such as analgesic action, inhibitory effect on nitrogen monoxide synthetase and the like and are useful as analgesics. The derivatives of the invention are also useful as therapeutic or prophylactic agents for septicemia, endotoxin shock, chronic articular rheumatism, etc.
|
申请公布号 |
CA2331468(C) |
申请公布日期 |
2005.06.28 |
申请号 |
CA19992331468 |
申请日期 |
1999.05.17 |
申请人 |
OTSUKA PHARMACEUTICAL FACTORY, INC. |
发明人 |
OKUMURA, TAKASHI;SHOJI, YASUO;SHIBUTANI, TADAO;YASUDA, TSUNEO;IWAMOTO, TAKESHI |
分类号 |
C07D487/04;(IPC1-7):C07D487/04;A61K31/505 |
主分类号 |
C07D487/04 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|