发明名称 |
ПОЛУСИНТЕТИЧЕСКИЙ СПОСОБ ПОЛУЧЕНИЯ N-ДЕБЕНЗОИЛПАКЛИТАКСЕЛА |
摘要 |
A process for the preparation of N-debenzoylpaclitaxel (I) through esterification of 7-protected baccatin III with a carboxylic acid reactive derivative of general formula (II), and elimination of the ester-protecting groups in acid conditions and in a single step. In formula (II) R1 is aryl or heteroaryl. The compound of formula (I) can be conveniently used for the preparation of paclitaxel and analogues |
申请公布号 |
RU2004130316(A) |
申请公布日期 |
2005.06.27 |
申请号 |
RU20040130316 |
申请日期 |
2003.03.24 |
申请人 |
ИНДЕНА С.П.А. (IT) |
发明人 |
БОМБАРДЕЛЛИ Эцио (IT);ФОНТАНА Габриеле (IT) |
分类号 |
C07B51/00;C07B61/00;C07D263/04;C07D263/06;C07D305/14;C07D413/12 |
主分类号 |
C07B51/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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