| 发明名称 |
ИНГИБИРУЮЩИЙ АКТИВНОСТЬ АГГРЕКАНАЗЫ ПЕПТИДНЫЙ АНАЛОГ ТРОМБОСПОНДИНА С ГИДРОКСАМОВОЙ КИСЛОТОЙ |
| 摘要 |
The present invention concerns the generation of hydroxamic acid thrombospondin-peptide analogs that inhibit aggrecanase activity. These analogs are useful in the treatment of diseases characterized by cartilage degradation, such as osteoarthritis, rheumatoid arthritis spondylarthropathies, and septic arthritis. The invention describes a novel small molecule, enzyme inhibitor that binds both the enzyme and its naturally occurring substrate. |
| 申请公布号 |
RU2004100273(A) |
申请公布日期 |
2005.06.27 |
| 申请号 |
RU20040100273 |
申请日期 |
2002.07.09 |
| 申请人 |
Эм Пи БАЙОМЕДИКАЛЗ, ИНК. (US) |
发明人 |
ТОРТОРЕЛЛА Майкл (US);ВАНГ Дзинхай (US);БЭЛХОРН Родни Л. (US) |
| 分类号 |
A61K38/55;A61K31/16;A61K31/166;A61K31/501;A61K31/706;A61K38/00;A61P19/02;A61P19/08;A61P29/00;A61P43/00;C07C259/06;C07K7/08;C07K14/00;C07K14/78 |
主分类号 |
A61K38/55 |
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