НОВЫЕ ПРОИЗВОДНЫЕ ИМИДАЗОЛИДИНА, ИХ ПОЛУЧЕНИЕ И ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ АНТАГОНИСТОВ VLA-4

摘要

The present invention relates to novel imidazolidine derivatives of the formula I, in which B, E, W, Y, R, R², R³, R³⁰, e and h have the meanings given herein. The compounds of the formula I are valuable pharmaceutically active compounds which are suitable, for example, for treating inflammatory diseases, for example, rheumatoid arthritis, or allergic diseases. The compounds of the formula I are inhibitors of the adhesion and migration of leukocytes and/or antagonists of the adhesion receptor VLA-4, which belongs to the integrin group. They are generally suitable for treating diseases which are caused by, or associated with, an undesirable degree of leukocyte adhesion and/or leukocyte migration or in which cell-cell or cell-matrix interactions, which are based on the interactions of VLA-4 receptors with their ligands, play a role. The invention furthermore relates to processes for preparing the compounds of the formula I, to their use and to pharmaceutical preparations which comprise compounds of the formula I.