Novel cyclic amide derivatives

摘要

Describes compounds represented by the formula (I) or a salt thereof, or a hydrate or a solvate thereof: wherein: X represents alkyl, cycloalkyl-substituted alkyl, aryl-substituted alkyl, aryl-substituted alkenyl, aryl-substituted alkynyl, monocyclic or polycyclic cycloalkyl which may be substituted with an alkyl, aryl, heterocyclic group, or substituted or unsubstituted amino group; Q represents a group represented by -CH2-, -CO-, -O-, -S-, -CH(OR7)-, -C(=CH2)- or -(=NR8)- wherein R represents a hydrogen, alkyl, hydroxyalkyl, or an acyl group, and R8 represents a hydroxyl, alkoxyl, aralkyloxy, acyloxy, acylamino, or an alkoxycarbonyl amino group; n represents an integer of from 0 to 5; R1 and R2 each independently represent a hydrogen atom or an alkyl group, or R1 and R2 combine to form an alkylene group; B represents either of the groups defined in formula (II): Further describes the use of the compounds of formula (I) in the manufacture of a medicament, which is used for a disease that can be therapeutically and/or preventatively treated by nerve controlling function of a sigma ligand, in a patient in need thereof.