1,2-dihydropyridine compounds, manufacturing method thereof and use thereof

摘要

Disclosed herein are compounds exhibiting inhibitory activities against AMPA receptor and/or kainate receptor, specifically compounds of the general formula (I), salts of the same, or hydrates of both, wherein Q is NH, O, or S; and R1, R2, R3, R4 and R5 are each independently hydrogen, halogen, C1-6 alkyl, or a group of the general formula: -X-A (wherein X is a single bond, optionally substituted C1-6 alkylene, or the like; and A is, e.g., a C6-14 aromatic carbocyclic group or a 5- to 14-membered aromatic heterocyclic group, any of which may be optionally substituted).