Endotoxin binding by lactobacillus and bifidobacteria having hydrophobic surface properties and use of the bacteria in treating endotoxin ( LPS ) mediated disorders

摘要

Described are isolated strains of lactic acid bacteria or bifidobacteria having hydrophobic surface properties wherein the percent hydrophobicity is at least 80% and the ability to bind endotoxins, provided the bifidobacteria is Bifidobacterium bifidum NCC189 (CNCM-I-2333) or Bifidobacterium bifidum NCC 235 (CNCM-I-2335). The bacteria can be used in human or pet food compositions associated with an ingestible support or a pharmaceutical matrix and are useful preventing or treating endotoxin mediated disorders. Preferred strains are Lactobacillus acidophilus NCC 2463 (CNCM-I 2623), Bifidobacterium bifidum NCC 251 (CNCM-I-2168) and Bifidobacterium lactis (ATCC 27536).