TRANSDERMAL SYSTEM FOR SUSTAINED DELIVERY OF POLYPEPTIDES

摘要

The present invention relates to a transdermal system for sustained delivery of high molecular weight hydrophilic drugs, especially peptide-, polypeptide - or protein-drugs and to methods of use thereof. The system comprises an apparatus that generates micro-channels in the skin of a subject in conjunction with a transdermal patch comprising at least one drug reservoir layer comprising a polymeric matrix and a therapeutic or immunogenic peptide , polypeptide or protein. The system provides sustained delivery of therapeuti c or immunogenic agents, thereby achieving sustained therapeutic blood concentrations of these agents.