摘要 |
The present invention relates to a compound formula[I]: wherein X is bond, -CH<SUB>2</SUB>-, -O- or -NH-, R<SUP>1 </SUP>and R<SUP>12 </SUP>are each independently hydrogen, halogen, lower alkyl, etc., R<SUP>2 </SUP>is hydrogen or optionally substituted lower alkyl, R<SUP>3 </SUP>is hydrogen or an amino protective group, R<SUP>4</SUP>, R<SUP>5 </SUP>and R<SUP>6 </SUP>are each independently hydrogen or optionally substituted lower alkyl, R<SUP>7 </SUP>is -Z-R<SUP>13</SUP>, in which Z is bond, etc., and R<SUP>13 </SUP>is carboxy, lower alkoxycarbonyl, (lower alkylsulfonyl)carbamoyl or lower alkanoylsulfamoyl, R<SUP>8 </SUP>is -Y-R<SUP>9</SUP>, in which Y is bond, -CH<SUB>2</SUB>-, -O-, -S-, etc., and R<SUP>9 </SUP>is hydrogen, lower alkyl, cyclo(lower)alkyl, etc., and R<SUP>11 </SUP>is hydrogen, lower alkyl, lower alkoxy, etc., or a salt thereof. The compound [I] of the present invention and pharmaceutically acceptable salts thereof are useful for the prophylactic and/or the therapeutic treatment of pollakiurea or urinary incontinence.
|