Indole derivative having heterocycle and mono- or diazaindole derivative

摘要

There is provided a compound represented by the general formula (1): wherein Het represents an optional substituted heterocylic group A₁ and A₂ each independently represent -CH-, etc.; A₃ represents -CH₂-, etc.; R₁ represents a 4-fluorophenyl group, etc.; R₂ represents an alkyl group; n represents 0, 1 or 2, provided that when A₁ and A₂ both are -CH-, A₃ represents -CH₂- or -SO₂-, which is an indole derivative or a mono- or diazaindole derivative that has COX-2 inhibitory activity and is useful as a pharmaceutical, such as an anti-inflammatory agent, or addition salts thereof with a pharmaceutically acceptable acid or base, or hydrates thereof.