DISEASE MODEL ANIMAL EXPRESSING MEGSIN/RAGE/iNOS AND METHOD OF EVALUATING COMPOUND WITH THE USE OF THE ANIMAL
摘要
<p>A triple Tg (megsin/RAGE/iNOS-Tg) is constructed by crossing a megsin-Tg with an RAGE/iNOS-Tg. It is found out that this megsin/RAGE/iNOS-Tg suffers from the onset of remarkable diabetic kidney lesion at an early stage which has never been observed so far and shows various uniform lesion images such as glomerular enlargement. It is also found out that the animal showing these symptoms is useful as a model animal of diabetic nephropathy. That is to say, the disease model animal as described above overexpresses megsin gene, receptor for advanced glycation end product gene and inducible nitric oxide synthase gene and, therefore, suffers from renal dysfunction associated with glomerular disorders at an early stage.</p>
申请公布号
WO2005055706(A1)
申请公布日期
2005.06.23
申请号
WO2004JP18413
申请日期
2004.12.09
申请人
JAPAN SCIENCE AND TECHNOLOGY AGENCY;GENE THESIS CO., LTD.;MIYATA, TOSHIO;KUROKAWA, KIYOSHI;YAMAMOTO, HIROSHI;OKAMOTO, HIROSHI