发明名称 |
Targeted gene delivery to non-phagocytic mammalian cells via bacterially derived intact minicells |
摘要 |
A method of targeting bacterially-derived, intact minicells to specific, non-phagocytic mammalian cells employs bispecific ligands to deliver nucleic acids efficiently to the mammalian cells. Bispecific ligands, comprising (i) a first arm that carries specificity for a bacterially-derived minicel surface structure and (ii) a second arm that carries specificity for a non-phagocytic mammalian cell surface receptor are useful for targeting minicells to specific, non-phagocytic mammalian cells and causing endocytosis of minicells by non-phagocytic cells. |
申请公布号 |
AU2004297414(A1) |
申请公布日期 |
2005.06.23 |
申请号 |
AU20040297414 |
申请日期 |
2004.12.08 |
申请人 |
ENGENEIC MOLECULAR DELIVERY PTY LTD |
发明人 |
JENNIFER MACDIARMID;HIMANSHU BRAHMBHATT |
分类号 |
C12N15/85;A61K48/00;C12N15/88 |
主分类号 |
C12N15/85 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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