| 摘要 |
A process for the preparation of tetrahydrothieno[3,2-c]pyridine compound of formula 6: or their pharmaceutically acceptable salts, wherein the meaning of X is carboxyl, alkoxycarbonyl, aryloxycarbonyl, or carbamoyl of formula wherein R<SUB>1 </SUB>and R<SUB>2 </SUB>can be individually or simultaneously hydrogen, alkyl or part of a heterocyclic structure; Z can be hydrogen, halogen, alkyl, aryl, aryloxy or alkoxy group, the process comprising conducting a dehydroxylation reaction on the compound of formula 5 in order to obtain a compound of formula 6, wherein said dehydroxylation reaction is effected by iodosilane represented by the formula Si(R<SUB>3</SUB>)<SUB>3</SUB>I, wherein R<SUB>3 </SUB>selected from an alkyl, alkenyl, alkynyl, aromatic group, or combinations of thereof.
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