ANTI-MPL ANTIBODY

摘要

Antihuman Mpl antibody is obtained and purified. By using a genetic engineering technique, antihuman Mpl diabody and antihuman Mpl sc(Fv)2 are purified. Furthermore, the antihuman Mpl sc(Fv)2 is successfully humanized. As the results of the evaluation on the TPO-like agonistic activities of the diabody and the sc(Fv)2, it is found out that the diabody and the sc(Fv)2 sh ow high agonistic activities to antihuman Mpl antibody and their activities are comparable or even superior to the activity of human TPO which is a natural ligand.