| 摘要 |
The present invention relates to co-extruded pharmaceutical compositions and dosage forms including an active agent, such as an opioid agonist, and an adverse agent, such as an opioid antagonist. Such compositions and dosage forms are useful for preventing or discouraging tampering, abuse, misuse or diversion of a dosage form containing an active pharmaceutical agent, such a s an opioid. The present invention also relates to methods of treating a patie nt with such a dosage form, as well as kits containing such a dosage form with instructions for using the dosage form to treat a patient.
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