METHODS OF DESIGNING, SYNTHESIZING, AND PROPAGATING REFERENCE NUCLEIC ACIDS

摘要

Subject matter includes design, synthesis, and propagation of synthetic and semi-synthetic reference nucleic acids and mixtures of reference nucleic aci ds for use in genetic tests, such as molecular screening, mutation testing, carrier testing, and diagnostic assays. In one implementation, methods are described for design, synthesis, and propagation of reference nucleic acid mixtures and a system is presented for using the mixtures.