发明名称 |
Isolated nucleic acids, vectors and host cells encoding ErbB3 antibodies |
摘要 |
Antibodies are disclosed which bind to ErbB3 protein and further possess any one or more of the following properties: an ability to reduce heregulin-induced formation of an ErbB2-ErbB3 protein complex in a cell which expresses ErbB2 and ErbB3; the ability to increase the binding affinity of heregulin for ErbB3 protein; and the characteristic of reducing heregulin-induced ErbB2 activation in a cell which expresses ErbB2 and ErbB3.
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申请公布号 |
US2005136494(A1) |
申请公布日期 |
2005.06.23 |
申请号 |
US20050051056 |
申请日期 |
2005.02.04 |
申请人 |
GENENTECH, INC. |
发明人 |
AKITA ROBERT;SLIWKOWSKI MARK |
分类号 |
A61P35/00;C07K16/32;C12N5/20;(IPC1-7):G01N33/574;C07K16/30 |
主分类号 |
A61P35/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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