发明名称 |
Identification of genes involved in Alzheimer's disease using Drosophila melanogaster |
摘要 |
Transgenic flies displaying altered phenotypes due to expression of the Abeta and C 99 portions of the human APP gene are disclosed. Use of these flies in a method to identify Drosophila genes and the human homologs of these Drosophila genes, that are potentially involved in Alzheimer's Disease, is also disclosed. The use of said human homologs as drug targets for the development of therapeutics to treat Alzheimer's Disease and other conditions associated with defects in the APP pathway, as well as pharmaceutical compositions comprising substances directed to these genes, are also disclosed.
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申请公布号 |
US2005138676(A1) |
申请公布日期 |
2005.06.23 |
申请号 |
US20040975523 |
申请日期 |
2004.10.28 |
申请人 |
COHEN DALIA;DENGLER UWE J.;FINELLI ALYCE L.;FREULER FELIX;KONSOLAKI MARY;REINHARDT MISCHA W.H.;ZUSMAN SUSAN |
发明人 |
COHEN DALIA;DENGLER UWE J.;FINELLI ALYCE L.;FREULER FELIX;KONSOLAKI MARY;REINHARDT MISCHA W.H.;ZUSMAN SUSAN |
分类号 |
A01K67/027;A01K67/033;A61K38/00;A61K45/00;A61K48/00;A61P25/28;A61P43/00;C07K14/47;C12N15/09;C12Q1/68;G01N33/15;G01N33/50;G01N33/53;G01N33/566;(IPC1-7):A01K67/033 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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地址 |
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