发明名称 |
Method of site specific labeling of proteins and uses therefor |
摘要 |
Methods for site-specific modification of protein are provided. These methods modify proteins which have been labeled at a particular site by the reaction of a transglutaminase with a glutamine peptide sequence which has been engineered into the protein. The site-specific modification methods of the invention are useful for producing reagents useful in high throughput screening methods and in producing protein delivery vehicles for specifically targeting cellular and non-cellular targets. Also described are improved biotinylation reagents.
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申请公布号 |
US2005136491(A1) |
申请公布日期 |
2005.06.23 |
申请号 |
US20040013016 |
申请日期 |
2004.12.15 |
申请人 |
SMITHKLINE BEECHAM CORPORATION |
发明人 |
CHEN WENFANG;MEEK THOMAS D.;POWELL DAVID J.;TEW DAVID G. |
分类号 |
G01N33/53;C07K1/02;C07K14/00;C12N15/09;C12P21/02;C12Q1/02;G01N21/78;G01N33/15;G01N33/50;G01N33/532;G01N33/566;G01N33/58;G01N33/68;(IPC1-7):G01N33/53;C07K7/08;C07K7/06 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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