COMPOSITIONS AND METHODS FOR TREATMENT OF PSYCHIATRIC DISORDERS

摘要

An agent selected from: (i) dopamine; (ii) a dopamine precursor: (iii) a dopamine D1-R agonist: (iv) a combination of dopamine and a dopamine precursor; (v) a combination of dopamine, a dopamine precursor or a dopamine D1-R agonist with a dopamine D2-R antagonist; (vi) a modified CNS-peptide; (vii) T cells that have been activated either by a CNS-specific antigen or by a modified CNS-peptide; and (viii) poly-YE, a poly-YE related peptide or polypeptide, can cause down-regulation of the suppressive activity of CD4+CD25+ regulatory T (Treg) cells on CD4+CD25- effector T cells (Teff), modulation of the immune response and/or modulation of autoimmune response, and are useful for treatment of psychiatric disorders.