发明名称 |
TRITYL DERIVATIVES FOR ENHANCING MASS SPECTROMETRY |
摘要 |
The present invention provides a method of forming an ion of formula (I) comprising the steps of: (i) reacting a compound of the formula (IIa); with a biopolymer, BP, having at least one group capable of reacting with M to form a covalent linkage, to provide a biopolymer derivative of the formula (IIIa); and (ii) cleaving the C-X bond between X and the a-carbon atom of the derivative of formula (IIIa) to form the ion of formula (I); where: C * is a carbon atom bearing a single positive charge or a single negative charge; and X is a group capable of being cleaved from the a-carbon atom to form an ion of formula (I). The biopolymer derivatives of the invention have enhanced ionisability with respect to free biopolymer (BP) enabling improved analysis of the biopolymer using mass spectrometry. |
申请公布号 |
WO2005057207(A1) |
申请公布日期 |
2005.06.23 |
申请号 |
WO2004GB05140 |
申请日期 |
2004.12.08 |
申请人 |
OXFORD GENE TECHNOLOGY IP LIMITED;SHCHEPINOV, MIKHAIL, SERGEEVICH;SOUTHERN, EDWIN, MELLOR |
发明人 |
SHCHEPINOV, MIKHAIL, SERGEEVICH;SOUTHERN, EDWIN, MELLOR |
分类号 |
C07C43/23;C07C205/43;C07C215/32;C07C235/42;C07C331/28;C07D207/40;C07D207/416;C07D207/44;C07D207/452;C07D207/46;C07D211/46;C07D333/16;C07D335/16;C07D409/14;C07D491/16;C07D493/08;C07H21/00;C07K17/06;G01N33/48;G01N33/68 |
主分类号 |
C07C43/23 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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