| 发明名称 |
WATER-SOLUBLE ETOPOSIDE ANALOGS AND METHODS OF USE THEREOF |
| 摘要 |
<p>Etoposide analogs with improved water-solubility such as 4'-O-Demethyl-4'-(N', N'-dimethyl-glycyl)-4beta-(4"-nitroanilino)-4-desoxy-podophyllotoxin (8) and 4'-O-Demethyl-4'-(N', N'-dimethyl-glycyl)-4beta-(4"-fluoroanilino)-4-desoxy-podophyllotoxin (9) are described, along with pharmaceutical formulations containing the same, methods of use thereof, and intermediates and methods of making the same.</p> |
| 申请公布号 |
WO2005056549(A1) |
申请公布日期 |
2005.06.23 |
| 申请号 |
WO2004US26475 |
申请日期 |
2004.08.17 |
| 申请人 |
US;US;US;US |
发明人 |
LEE, KUO-HSIUNG;XIAO, ZHIYAN;BASTOW, KENNETH, F. |
| 分类号 |
A61K31/497;A61K31/335;A61K31/44;A61K31/445;C07D405/14;C07D407/00;C07D409/00;C07D453/02;C07D493/04;C07D497/04;(IPC1-7):C07D409/00 |
主分类号 |
A61K31/497 |
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