发明名称 |
CONFORMATIONALLY CONSTRAINED PARATHYROID HORMONE (PTH) ANALOGS |
摘要 |
The invention provides novel P1R polypeptide antagonists. These antagonists contain amino acid substitutions at selected positions in truncated PTH and PRHrP polypeptides and function by binding selectively to the juxtamembrane ("J") domain of the receptor. The J domain is the region of the receptor that spans the seven transmembrane domain and the extracellular loops. |
申请公布号 |
WO2005009358(A3) |
申请公布日期 |
2005.06.23 |
申请号 |
WO2004US22830 |
申请日期 |
2004.07.16 |
申请人 |
THE GENERAL HOSPITAL CORPORATION;GARDELLA, THOMAS, J. |
发明人 |
GARDELLA, THOMAS, J. |
分类号 |
A61K;A61K38/00;C07K14/635 |
主分类号 |
A61K |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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