| 摘要 |
The present invention provides a method for obtaining an immunogenic, non haemolytic strain of Actinobacillus pleuropneumoniae which is modified, at least in a segment of the apxIA gene and optionally in a segment of the apxIIA gene that codes a transmembrane domain of the Apx haemolytic and cytolytic exotoxins. It comprises also the strains, and the attenuated live vaccine against porcine pleuropneumonia obtained therewith.
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