发明名称 |
Glucoimidazole and polyhydroxycyclohexenyl amine derivatives to treat gaucher disease |
摘要 |
The present invention provides glucoimidazole (GIZ) and polyhydroxycyclohexenyl amine (PHCA) derivatives, methods of making them, and methods of use where the GIZ and PHCA derivatives have a short, flexible linker emanating from the corresponding position of the ring oxygen in a pyranose; and a lipophilic moiety connected to the linker and pharmaceutically acceptable salts thereof. More particularly, the present invention further provides a method for treating individuals having Gaucher disease by administering the novel GIZ or PHCA derivatives as "active-site specific chaperones" for the mutant glucocerebrosidase associated with the disease.
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申请公布号 |
US2005137223(A1) |
申请公布日期 |
2005.06.23 |
申请号 |
US20040988427 |
申请日期 |
2004.11.12 |
申请人 |
AMICUS THERAPEUTICS, INC. |
发明人 |
FAN JIAN-QIANG;ZHU XIAOXIANG;SHETH KAMLESH |
分类号 |
A61K;A61K31/437;A61K31/445;A61K31/454;A61K31/4745;A61K31/50;A61K31/501;A61K48/00;A61P43/00;C07D211/40;C07D471/02;C07D471/04;(IPC1-7):C07D471/02;A61K31/474 |
主分类号 |
A61K |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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