Modulators of phosphoinositide 3-kinase

摘要

Compounds of formula 1 are effective modulators of PI3 kinase: wherein R₁ is H, hydroxy, amino, lower alkyl, or trihalomethyl; R₂ is amino, lower alkylamino, lower acylamino, arylamino, arylacyl-amino, heteroaryl-amino, heteroaryl-acyl amino, where aryl and heteroaryl are substituted with 0-3 substituents selected from the group consisting of halo, trihalomethyl, hydroxy, lower alkyl and lower alkoxy, or a substituent of the form -(CH₂)_n-C(-X)-R₈, where n is 014 3 inclusive and X is O or NR₉, where R₉ is H, lower alkyl, or R₁ and R₂ together form -CH-N-X- where X is CH, NH, O, or S, and R₈ is H, lower alkyl, lower alkoxy, aryl, aralkyl, or -(CH₂)_mCR₁₀R₁₁R₁₂, where m is 0-3 inclusive, and R₁₀, R₁₁, and R₁₂ are each independently H, lower alkyl, aryl, aralkyl, hydroxy, lower alkoxy, aryloxy, aralkoxy, amino, lower alkyl-amino, arylamino, aralkylamino, heteroaryl amino, or heteroaralkyl amino, where aryl and heteroaryl are substituted with 0-3 substituents selected from the group consisting of halo, hydroxy, and lower alkyl; R₃ is H or lower alkyl; and R₄, R₅, R₆, R₇ are each independently H, halo, hydroxy, amino, nitro, lower alkyl, or lower alkoxy; and pharmaceutically acceptable salts thereof.