发明名称 |
Thioester polymer derivatives and method of modifying the N-terminus of a polypeptide therewith |
摘要 |
The invention provides reagents and methods for conjugating polymers specifically to the alpha-amine of polypeptides in high yield. The invention provides monofunctional, bifunctional, and multifunctional PEGs and related polymers having a thioester moiety capable of specifically conjugating to the alpha-amine of a polypeptide having a cysteine or histidine at the N-terminus. The invention provides active thioester derivatives of PEG that have suitable reactivity with an N-terminal cysteine or histidine residue of a polypeptide to produce an amide bond between the PEG and polypeptide. Use of these active esters to prepare PEG-proteins and PEG-peptides is described.
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申请公布号 |
US6908963(B2) |
申请公布日期 |
2005.06.21 |
申请号 |
US20010973318 |
申请日期 |
2001.10.09 |
申请人 |
NEKTAR THERAPEUTICS AL, CORPORATION |
发明人 |
ROBERTS MICHAEL J.;FANG ZHIHAO |
分类号 |
C07K1/113;A61K47/48;C07K14/555;C08G65/334;(IPC1-7):C08G63/50 |
主分类号 |
C07K1/113 |
代理机构 |
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主权项 |
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地址 |
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