| 摘要 |
The invention comprises 4-fluoro-3-sulphamoyl -benzamide; its preparation by chlorosulphonating p-fluorobenzoic acid to form 4-fluoro-3-chlorosulphonyl-benzoic acid, reacting with a chlorinating agent such as thionyl chloride and treating the resulting 4-fluoro-3-chlorosulphonyl benzoyl chloride with ammonia; and pharmaceutical preparations having diuretic activity comprising the above sulphonamide and a nontoxic carrier, preparably in a form suitable for administration via the digestive tract, such as tablets, cachets, capsules or suppositories. |
