| 摘要 |
The present invention relates to novel intermediates for the preparation of 3-methylenecephams of the formula IIA. wherein: R is a carboxylic acid protecting group; R<SUB>1 </SUB>is a group of the formula; R<SUB>10 </SUB>is C<SUB>1</SUB>-C<SUB>6 </SUB>alkyl, C<SUB>1</SUB>-C<SUB>6 </SUB>polyfluoroalkyl, C<SUB>3</SUB>-C<SUB>6 </SUB>cycloalkyl, adamantyl, phenyl, substituted phenyl, phenyl(C<SUB>1</SUB>-C<SUB>3 </SUB>alkyl), diphenylmethyl, or substituted phenyl(C<SUB>1</SUB>-C<SUB>3 </SUB>alkyl), or a group of the formula Z is solid polymer support; and Z<SUB>1 </SUB>is one or two groups independently selected from the group consisting of hydrogen, halo, hydroxy, protected hydroxy, nitro, cyano, trifluoromethyl, C<SUB>1</SUB>-C<SUB>4 </SUB>alkyl, and C<SUB>1</SUB>-C<SUB>4 </SUB>alkoxy.
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