NEW CARTHARIDIC AMINE, DEMETHYL CARTHARIDIC AMINE DERIVATIVES AND THEIR MEDICINAL USE

摘要

The invention relates to new cartharidic amine and demethyl cartharidic amine derivatives (I), and their intermediates (II), wherein P is glycol oligomer or amido acid oligomer, and the conjugates (III) of demethyl cartharidic amine derivatives (I) and polyglycol. Cartharidic amine and demethyl cartharidic amine derivatives (I), their intermediates (II), and the conjugates (III) have improved water solubility, less toxicity and side effect, inhibit enhanced activity of anti-cancer.