Disclosed are methods and compositions for modulation of ion levels in cells. The compositions contain in a new class of biologically active peptides derived from the venom of predatory marine snails of the species Conus gladiator and Conus mus. The active peptides, termed gamma-hydroxyconophans are heavily hydroxylated small peptides. These peptides contain a definitive structural motif which is a double modification of the polypeptide chain in contiguous residues, i.e., gamma-OH-Hyv-D-Trp.
申请公布号
WO2004078779(A3)
申请公布日期
2005.06.16
申请号
WO2004US07046
申请日期
2004.03.05
申请人
FLORIDA ATLANTIC UNIVERSITY;MARI, FRANK;FIELDS, GREGG, B.