Amelioration of cataracts, macular degeneration and other ophthalmic diseases

摘要

Ophthalmically acceptable compositions used in arresting the development of cataract, presbyopia, macular degeneration and other retinopathies, glaucoma, uveitis and various corneal disorders are disclosed. The compositions are also useful as a prophylactic treatment to prevent or delay development of age-related ocular disorders, which include cataracts, presbyopia, glaucoma and macular degeneration. The compositions comprise a pharmaceutically acceptable carrier or diluent and at least one compound having the formula: where R₁ and R₂ are, independently, H or C₁ to C₃ alkyl; R₃ and R₄ are, independently C₁ to C₃ alkyl; and where R₁ and R₂, taken together, or R₃ and R₄, taken together, or both may be cycloalkyl; R₅ is H, OH, or C₁ to C₆ alkyl; R₆ is or C₁ to C₆ alkyl, alkenyl, alkynyl, or substituted alkyl or alkenyl; R₇ is C₁ to C₆ alkyl, alkenyl, alkynyl, or substituted alkyl or alkenyl or where R₆ and R₇, or R₅, R₆ and R₇, taken together, form a carbocycle or heterocycle having from 3 to 7 atoms in the ring.