DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH PROTEIN-COUPLED INWARDLY RECTIFYING POTASSIUM CHANNEL (GIRK2)

摘要

The invention provides a human GIRK2 which is associated with the cardiovascular diseases, endocrinological diseases, metabolic diseases, inflammation, gastroenterological diseases, neurological diseases, urological diseases and respiratory diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, endocrinological diseases, metabolic diseases, inflammation, gastroenterological diseases, neurological diseases, urological diseases and respiratory diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of GIRK2 as well as pharmaceutical compositions comprising such compounds. BHC 03 1 016-Foreign Countries - 3 -