The invention features corticosteroids conjugated to either a charged group or a bulky group in a manner that resists in vivo cleavage, the resulting conjugate is a peripherally acting steroid with reduced activity in the central nervous system. The invention provides a method for treating a patient having an inflammatory disease by administering to the patient a corticosteroid conjugate.
申请公布号
WO2004017904(A3)
申请公布日期
2005.06.16
申请号
WO2003US26233
申请日期
2003.08.22
申请人
THE MCLEAN HOSPITAL CORPORATION;TEICHER, MARTIN, H.;ANDERSEN-NAVALTA, SUSAN, L.