发明名称 |
A Method for the Enantiomoeric Separation of Optical Active Amlodipine |
摘要 |
<p>The Invention relate to the preparation of the (S)-(-)-amoldipine and (R)-(+)-amlodipine by means of enantiomoeric separation of racemic amlodipine mixture, in which, L- or D-tartaric acid is used as resolution agent, and organic solvent containing 2-butone is used as solvent. The 2-butone used in the present invention has the advantage of low boiling point, low toxicity, little pollution, and the method is suitable for large-scale production.</p> |
申请公布号 |
WO2005054196(A1) |
申请公布日期 |
2005.06.16 |
申请号 |
WO2004CN01412 |
申请日期 |
2004.12.03 |
申请人 |
SHIJIAZHUANG PHARMACEUTICAL GROUP OUYI PHARMA. CO., LTD.;ZHONG, NANPING;ZHAO, XIANFENG;MA, HUI;CHEN, YUJIE |
发明人 |
ZHONG, NANPING;ZHAO, XIANFENG;MA, HUI;CHEN, YUJIE |
分类号 |
A61P9/12;C07D211/90;(IPC1-7):C07D211/90 |
主分类号 |
A61P9/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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