Stereoselective synthesis of certain trifluoromethyl-substituted alcohols

摘要

A process for stereoselective synthesis of compounds of Formula X wherein: R¹ is an aryl or heteroaryl group, each optionally independently substituted with one to three substituent groups, wherein each substituent group of R¹ is independently C₁-C₅ alkyl, C₂-C₅ alkenyl, C₂-C₅ alkynyl, C₃-C₈ cycloalkyl, heterocyclyl, aryl, heteroaryl, C₁-C₅ alkoxy, C₂-C₅ alkenyloxy, C₂-C₅ alkynyloxy, aryloxy, C₁-C₅ alkanoyloxy, C₁-C₅ alkanoyl, aroyl, trifluoromethyl, trifluoromethoxy, or C₁-C₅ alkylthio, wherein each substituent group of R¹ is optionally independently substituted with one to three substituent groups selected from methyl, methoxy, fluoro, chloro, hydroxy, oxo, cyano, or amino; and R² and R³ are each independently hydrogen or C₁-C₅ alkyl, or R² and R³ together with the carbon atom they are commonly attached to form a C₃-C₈ spiro cycloalkyl ring.