GLYCOSYLATED TRIKETIDE DELTA LACTONES

摘要

The present invention relates to compounds of formula (1) and salts, stereoisomeric forms, racemic mixtures, prodrugs, esters and metabolites thereof, wherein R1 is a glycosyl moiety, hydroxyl-protected acetate derivatives thereof or amino derivatives thereof; R2, R3 an R4 are, each independently, selected from the group comprising hydrogen, C1-6alkyl, C2-20alkenyl, C6-20arylalkyl, C3-7cycloalkyl, C3-7cycloalkylC1-6alkyl, C6-20aryl aralkyl, akylcarbonyloxy, arylcarbonyloxy, alkyloxy, alklylthio, alkylamino, alkyloxyalkyl,. alkanoyl, alkylcarbonylalkyl, optionally substituted by one or more substituents independently selected from the group comprising alkyl, aralkyl, aryl, cycloalkyl, alkyloxycarbonyl, carboxyl, aminocarbonyl, hydroxy, cyano, halogen or amino optionally mono- or disubstituted wherein the substituents are independently selected from the group comprising alkyl, aryl, aralkyl, aryloxy, arylamino, aryloxyalkyl, arylaminoalkyl, aralkoxy, alkoxy.