HIGHLY SAFE SMALLPOX VACCINE VIRUS AND VACCINIA VIRUS VECTOR

摘要

It is intended to provide a vaccine strain scarcely undergoing atavism (reversion) to thereby provide a smallpox vaccine having an elevated safety. Namely, a vaccine virus lacking the whole or a part of B5R gene of a vaccinia virus strain LC16m8 or LC16m0 produces no B5R gene product having the normal function. This vaccine virus is usable as a smallpox vaccine and as a vector capable of expressing a foreign gene. Thus, a smallpox virus and a vaccinia virus vector producing no B5R gene product having the normal function by reverse mutation are provided.