发明名称 |
CRYSTALLINE SOLID FORM OF (2S,5Z)-2-AMINO-7-(ETHANIMIDOYLAMINO)-2-METHYLHEPT-5-ENOIC AICD |
摘要 |
2S,5Z)-2-amino-7-(ethanimidoylamino)-2- methylhept-5-enoic acid is crystallized as an anhydrous, stoichiometric 1. 5 HCl salt and a scaleable crystallization method is disclosed. The salt form was characterized and the absolute configuration of the chiral center was confirmed as "S". (2S,5Z)-2-amino-7-(ethanimidoylamino)-2- methylhept-5-enoic acid was high melting and appears acceptably non- hygroscopic for use in a pharmaceutical composition.
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申请公布号 |
KR20050058443(A) |
申请公布日期 |
2005.06.16 |
申请号 |
KR20057002999 |
申请日期 |
2005.02.22 |
申请人 |
PHARMACIA CORPORATION |
发明人 |
HALLINAN ANN E. |
分类号 |
A61P1/00;A61K31/155;A61K31/198;A61P1/02;A61P1/04;A61P1/12;A61P1/14;A61P1/18;A61P3/08;A61P3/10;A61P5/24;A61P7/00;A61P7/02;A61P9/00;A61P9/02;A61P9/04;A61P9/08;A61P9/10;A61P11/00;A61P11/06;A61P13/12;A61P15/00;A61P17/00;A61P17/02;A61P17/06;A61P21/04;A61P25/00;A61P25/02;A61P25/08;A61P25/14;A61P25/16;A61P25/20;A61P25/22;A61P25/24;A61P25/26;A61P25/28;A61P25/30;A61P25/36;A61P27/02;A61P27/06;A61P29/00;A61P31/04;A61P31/12;A61P35/00;A61P37/02;A61P37/04;A61P37/06;A61P39/02;A61P43/00;C07C257/14;(IPC1-7):C07C257/14 |
主分类号 |
A61P1/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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