Aerosol formulations for pulmonary administration of medicaments to produce a systemic effect

摘要

The invention discloses an aerosol pharmaceutical composition comprising a medicament in solution in a mixture of a hydrfluoroalkane propellant and one or more co-solvents wherein the aerosol liquid droplets delivered on actuation of the inhaler have a particle size comprised between 0.5 mum and 2.5 mum, with a mass median aerodynamic diameter of about 1-2 mum and wherein the fine particle fraction is at least 30%.