INHIBITORS OF GLYCOPROTEIN VI BASED ON MONOCLONAL ANTIBODY HGP 5C4

摘要

The present invention relates to a specific inhibitor of human platelet glycoprotein VI. The inhibitor may be an optionally humanized antibody or function-conservative fragments or variants thereof, a specific fusion protein or conjugate. Moreover, the present invention relates to pharmaceutical compositions containing the specific inhibitor of the invention. The present invention also relates to hybridomas expressing the antibody of the present invention. Furthermore, the present invention relates to the use of the specific inhibitor of glycoprotein VI for the preparation of a medicament for the prevention of acute and chronic vascular diseases associated with arterial and/or intravenous thrombosis, such as acute coronary syndrome, acute carotid artery syndrome, acute myocardial infarction, acute cerebral stroke and chronic coronary or peripheral vessel disease. Finally, the present invention relates to a process for preparing the antibody of the invention and to a process for preparing a specific fragment of the antibody of the present invention.