发明名称 |
DETECTION OF SOMATIC CELL MUTATION OF MITOCHONDRIA DNA FOR DETERMINING EFFECT OF ANTICANCER AGENT |
摘要 |
<p><P>PROBLEM TO BE SOLVED: To provide a method for discriminating anticancer agent sensitivity of a specimen by using mutation of a mitochondria gene of a specimen as an index and a kit for discriminating anticancer agent sensitivity of the specimen. <P>SOLUTION: The method for measuring sensitivity of a cell containing a mitochondria DNA of mutation type to an anticancer agent comprises fusing an enucleated cell containing the mitochondria DNA of mutation type with a mitochondria DNA-deficient cell to give a cybrid, culturing the cybrid in the presence of the anticancer agent and assaying the cybrid that caused apoptosis. <P>COPYRIGHT: (C)2005,JPO&NCIPI</p> |
申请公布号 |
JP2005151843(A) |
申请公布日期 |
2005.06.16 |
申请号 |
JP20030392778 |
申请日期 |
2003.11.21 |
申请人 |
NIPPON MEDICAL SCHOOL |
发明人 |
OTA SHIGEO;MIZUTANI SATOSHI;SHIDARA YUJIRO |
分类号 |
G01N33/50;C12N5/10;C12Q1/02;C12Q1/68;G01N33/15;(IPC1-7):C12Q1/02 |
主分类号 |
G01N33/50 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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