PHENANTHRIDINIUM DERIVATIVES AS DNA BINDING AGENTS
摘要
New classes of heterocyclic aromatic cationic compounds are disclosed, and in particular new classes of phenanthridinium derivatives, most notably dihydro-imidazo-phenanthridinium (DIP) compounds. These findings are based on the reaction of the middle b ring of a phenanthridinium core with primary amines to form DIP compounds (Formula A) or secondary amines to form 2-aminoalkyl phenanthridinium derivatives (Formula B). These reactions can also be applied to other classes of starting compounds which comprise a 6-membered ring aromatic heterocycle having a ring nitrogen and at least one alpha hydrogen atom which can be reacted with a primary or secondary amine.
申请公布号
WO2005054241(A2)
申请公布日期
2005.06.16
申请号
WO2004GB05004
申请日期
2004.11.26
申请人
THE UNIVERSITY COURT OF THE UNIVERSITY OF GLASGOW;PARENTY, ALEXIS;CRONIN, LEROY;BROWN, ROBERT