发明名称 |
OLIGONUCLEOTIDE ANALOG AND METHOD FOR TREATING FLAVIVIRUS INFECTIONS |
摘要 |
A method of inhibiting replication of a flavivirus in animal cells, and an oligonucleotide compound for use in the method are disclosed. The oligonucleotide analog (i) has a nuclease-resistant backbone, (ii) is capable of uptake by the cells, (iii) contains between 8-40 nucleotide bases, and (iv) has a sequence of at least 8 bases complementary to a region of the virus' positive strand RNA genome that includes at least a portion of SEQ ID NOS: 1-4. Exposure of cells infected with a flavivirus to the analog is effective to form within the cells, a heteroduplex structure composed of the virus ssRNA and the oligonucleotide, characterized by a Tm of dissociation of at least 45 °C., and having disrupted base pairing between the virus' 5' and 3' cyclization sequences. |
申请公布号 |
WO2005030800(A3) |
申请公布日期 |
2005.06.16 |
申请号 |
WO2004US25335 |
申请日期 |
2004.08.05 |
申请人 |
AVI BIOPHARMA, INC.;IVERSEN, PATRICK, L.;STEIN, DAVID, A. |
发明人 |
IVERSEN, PATRICK, L.;STEIN, DAVID, A. |
分类号 |
C12N15/113 |
主分类号 |
C12N15/113 |
代理机构 |
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代理人 |
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地址 |
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