Genetic reference standard

摘要

A genetic reference standard comprising at least one human genetic reference sequence cloned into a non-mammalian animal cell line. There is also provided such reference standards where the human DNA is targeted to specific location in the host genome, using homologous recombination. The invention further provides a method of detecting a genetic variant using such reference standards. The non-mammalian cell line is preferably an avian cell line, such as DT40.